BDBM50345712 3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1231372::CHEMBL2069314::US10544104, Compound 5h::US11247972, Compound 5h::US9765037, Compound 5h

SMILES Nc1ncnc2n(CC3CCNCC3)nc(Cc3cccc4ccccc34)c12

InChI Key InChIKey=MMRLNUFECMEMSQ-UHFFFAOYSA-N

Data  20 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50345712   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  15nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50345712(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Affinity DataIC50:  9nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In DepthDetails US Patent