BDBM50347085 CHEMBL1796271

SMILES CN(C(=O)c1cc2CCOc3ccccc3-c2s1)c1ccccc1Cl

InChI Key InChIKey=GMPBOYJSGBEFIG-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50347085   

LigandPNGBDBM50347085(CHEMBL1796271)
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as inhibition of PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347085(CHEMBL1796271)
Affinity DataKi:  16nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347085(CHEMBL1796271)
Affinity DataKi:  272nMAssay Description:Apparent binding affinity to PI3Kbeta using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347085(CHEMBL1796271)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PI3Kalpha-mediated AKT Ser 473 phosphorylation in human PC3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347085(CHEMBL1796271)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin)-mediated 3,4,5-inositoltriphosphate formation after 30 mins by TAMRA-PIP3-based competitive fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347085(CHEMBL1796271)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as inhibition of PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed