BDBM50347503 RADICICOL

SMILES C[C@@H]1C[C@@H]2O[C@@H]2C=CC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1

InChI Key InChIKey=WYZWZEOGROVVHK-ZWZTZDBGSA-N

Data  6 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50347503   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataIC50:  2.30E+5nMAssay Description:Inhibition of PDHK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibition of PDHK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataIC50:  16nMAssay Description:Binding affinity to Hsp90alpha N-terminal ATPase domain by TR-FRET assay based competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataIC50:  530nMAssay Description:Inhibition of Hsp90alpha ATPase activity by malachite green ATP-ase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataIC50:  20nMAssay Description:Inhibition of Hsp90More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataKd:  19nMAssay Description:The compound was tested for binding affinity against yeast Heat shock protein HSP 90More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to recombinant Hsp90 alpha (unknown origin) by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataIC50:  27nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent molecular chaperone HSP82(Saccharomyces cerevisiae)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataKd:  19nMAssay Description:Binding affinity to N-terminal ATP/ADP-binding domain of yeast Hsp90More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50347503(RADICICOL)
Affinity DataKd:  2.70nMAssay Description:The compound was tested for binding affinity against isolated N-domain of Heat shock protein HSP 90More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed