BDBM50349102 CHEMBL1236095::US11208696, Example 3

SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NC3CCN(C)CC3)nc-21

InChI Key InChIKey=JFOAJUGFHDCBJJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 78 hits for monomerid = 50349102   

TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 0.630nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
US Patent

TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataKi:  0.990nMAssay Description:Time-dependent inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) assessed as inhibition constant in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human MPS1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 4.90nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 3.3 uM ATP incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal 6XHis-tagged/GST-tagged full length human MPS1 expressed in recombinant baculovirus infected sf9 insect cells using 5FAM-DHT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 7.60nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 10 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 8nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant CK2 (unknown origin) preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant NEK6 (unknown origin) preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant MELK (unknown origin) preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 25nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 30 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 61nMAssay Description:Competitive inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of 90 uM ATP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataEC50:  65nMAssay Description:Inhibition of MPS1 in human nocodazole-arrested U2OS cells assessed as effect on histone H3 phosphorylation at ser10 residue incubated for 2 hrs by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant Mps1 (519-808 residues) (unknown origin) incubated for 10 min by invitro kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 160nMAssay Description:Inhibition of Myc-tagged wild type MPS1 autophosphorylation in human HCT116 cells after 2 hrs in presence of proteosome inhibitor MG132More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of full-length MPS1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of recombinant MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase TTK(Human)
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant MPS1 (2 to 857 residues) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant CK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 6.01E+3nMAssay Description:Inhibition of recombinant MELK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 6.02E+3nMAssay Description:Inhibition of recombinant NEK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant BUB1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant BRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CDK2/CYCE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CDK1/CYCB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CDC7/DBF4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CHK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CDK5/P25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CDK4/CYCD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant EEF2K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetActivated CDC42 kinase 1(Human)TBA
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant ACK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant IR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant IKK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant LYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant EGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetFocal adhesion kinase 1(Human)TBA
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
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