BDBM50349622 CHEMBL1808980

SMILES COc1nc(nc(n1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NCCN(C)C)cc1)N1CCOCC1

InChI Key InChIKey=MPVZERIWUAYICQ-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50349622   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50349622(CHEMBL1808980)Copy SMILESCopy InChI

Affinity DataIC50:  0.600nMAssay Description:Inhibition of human PI3Kalpha expressed in SF9 insect cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50349622(CHEMBL1808980)Copy SMILESCopy InChI

Affinity DataIC50:  5.60nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50349622(CHEMBL1808980)Copy SMILESCopy InChI

Affinity DataIC50:  10.5nMAssay Description:Inhibition of human PI3Kgamma expressed in SF9 insect cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI