BDBM50350790 BUPIVACAINE HYDROCHLORIDE::Bupivacaine::SAMPL3, G1

SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C

InChI Key InChIKey=LEBVLXFERQHONN-UHFFFAOYSA-N

Data  10 IC50  1 EC50  1 ITC

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50350790   

TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Korea Institute of Science and Technology

LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataEC50:  1.13E+5nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp techniqu...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of wild-type human ERG channel expressed in CHO cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetPotassium channel subfamily K member 3(Rattus norvegicus)
Universidad de Talca

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of rat TASK1 expressed in African green monkey COS7 cells by outside-out patches based electrophysiology assayMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Universidad de Talca

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assayMore data for this Ligand-Target Pair
TargetPotassium channel subfamily K member 9(Rattus norvegicus)
Universidad de Talca

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of rat TASK3 expressed in African green monkey COS7 cells by outside-out patches based electrophysiology assayMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50350790   

HostPNGBDBM197280(SAMPL3, H1)
University of California San Diego

GuestPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
ITC DataΔG°: -5.85kcal/mole logk: 1.80E+4
pH: 7.4 T: 24.85°C 
Cell InfoPC cidPC sid