BDBM50351015 CHEMBL1819176

SMILES Clc1ccc2c(NCCCCCCCNc3c4Cc5ccccc5-c4nc4ccccc34)c3CCCCc3nc2c1

InChI Key InChIKey=ASEDWXNMPGNYLM-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50351015   

TargetAcetylcholinesterase(Homo sapiens (Human))
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataKi:  1nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataIC50:  64nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataIC50:  1.10nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 expressed in baculovirus assessed as inhibition of amyloid beta-42 production after 60 mins by spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed