BDBM50357598 CHEMBL1915449
SMILES CN1CCN(CC1)c1ccc(Nc2nc3c(cccc3c3cnccc23)-c2nnc[nH]2)c(Cl)c1
InChI Key InChIKey=QOXRIMBHHVXCFG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50357598
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cylene Pharmaceuticals
Curated by ChEMBL
Cylene Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP]More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Cylene Pharmaceuticals
Curated by ChEMBL
Cylene Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISAMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cylene Pharmaceuticals
Curated by ChEMBL
Cylene Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PIM1 in presence of ATP by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Cylene Pharmaceuticals
Curated by ChEMBL
Cylene Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of FLT3 phosphorylation at Tyr591 in human MV-4-11 cells assessed as phospho-FLT3 level after 4 hrs by ELISAMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Cylene Pharmaceuticals
Curated by ChEMBL
Cylene Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]More data for this Ligand-Target Pair