BDBM50365426 CHEMBL1957085

SMILES COc1ccc(cc1)-c1ocnc1C(=O)NCc1ccncc1

InChI Key InChIKey=NDXJIXWTFPGHAI-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50365426   

TargetInsulin receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50:  398nMAssay Description:Inhibition of GSK3-beta by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50:  501nMAssay Description:Inhibition of CDK2 by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50:  79nMAssay Description:Inhibition of catalytic activity of GSK3-beta by AlphaLISA assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50:  794nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ASK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AurAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ITKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365426(CHEMBL1957085)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of GSK3beta-mediated CRMP-2 phosphorylation by cell based assayMore data for this Ligand-Target Pair