BDBM50366175 CHEMBL1957606

SMILES ONC(=O)[C@@H]1CS(=O)(=O)CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1

InChI Key InChIKey=LXQUQEBAZBLBEJ-HNNXBMFYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50366175   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Colosseum Combinatorial Chemistry Centre For Technology (C4T Scarl)

Curated by ChEMBL
LigandPNGBDBM50366175(CHEMBL1957606)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Colosseum Combinatorial Chemistry Centre For Technology (C4T Scarl)

Curated by ChEMBL
LigandPNGBDBM50366175(CHEMBL1957606)
Affinity DataIC50:  5nMAssay Description:Inhibition of MMP14 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Colosseum Combinatorial Chemistry Centre For Technology (C4T Scarl)

Curated by ChEMBL
LigandPNGBDBM50366175(CHEMBL1957606)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP8 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Colosseum Combinatorial Chemistry Centre For Technology (C4T Scarl)

Curated by ChEMBL
LigandPNGBDBM50366175(CHEMBL1957606)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Colosseum Combinatorial Chemistry Centre For Technology (C4T Scarl)

Curated by ChEMBL
LigandPNGBDBM50366175(CHEMBL1957606)
Affinity DataIC50:  19nMAssay Description:Inhibition of MMP12 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed