BDBM50366305 CHEBI:70328::CHEMBL445599

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6@H](-[#6][C@]12[#6]-[#6@H](-[#6]\[#6]=[#6](\[#6])-[#6])C([#6])([#6])[C@]([#6]\[#6]=[#6](\[#6])-[#6])([#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)=[#6]1-[#8])[#6]2=O)-[#6](-[#6])=[#6]

InChI Key InChIKey=QDKLRKZQSOQWJQ-AKAMJVKKSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50366305   

TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  300nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  500nMAssay Description:Inhibition of human p300 expressed in Escherichia coli incubated for 15 mins followed by [3H]acetyl-CoA/histone additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of full length His6-tagged recombinant p300 (unknown origin) expressed in baculovirus infected Sf21 cells using human histone as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
European Biomedical Research Institute Of Salerno (Ebris)

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  1.01E+5nMAssay Description:Inhibition of human topoisomerase 2beta-mediated relaxation of supercoiled pSG483 DNA after 30 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of recombinant FLAG epitope-tagged human PCAF expressed in Baculovirus-infected Sf21 cells using histone as substrate after 10 mins in pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of recombinant human full-length His6-tagged p300 expressed in baculovirus infected Sf21 insect cells using [3H]acetylCoA as substrate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
European Biomedical Research Institute Of Salerno (Ebris)

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  1.01E+5nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pSG483 DNA after 30 mins by ethidium bromide staining based agarose gel e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of recombinant full-length His6-tagged human P300 expressed in Baculovirus-infected Sf21 cells using histone as substrate after 10 mins in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed