BDBM50372514 CHEMBL540966

SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2cccnc12

InChI Key InChIKey=HXWOKTOKXJLLRZ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50372514   

TargetNF-kappa-B inhibitor alpha(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50372514(CHEMBL540966)
Affinity DataEC50:  6.50E+3nMAssay Description:Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Bos taurus (Bovine))
University Of Karachi

Curated by ChEMBL
LigandPNGBDBM50372514(CHEMBL540966)
Affinity DataIC50:  3.13E+4nMAssay Description:Compound was tested for TXA2 receptor antagonism by measuring its ability to inhibit contraction of rat aorta induced by the stable TXA2 agonist U-46...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNF-kappa-B inhibitor alpha(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50372514(CHEMBL540966)
Affinity DataEC50:  1.70E+4nMAssay Description:Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50372514(CHEMBL540966)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed