BDBM50378060 CUCURBITACIN B

SMILES CC(=O)OC(C)(C)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

InChI Key InChIKey=IXQKXEUSCPEQRD-QATBOUOLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50378060   

TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50378060(CUCURBITACIN B)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of STAT3 by western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50378060(CUCURBITACIN B)
Affinity DataIC50:  270nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50378060(CUCURBITACIN B)
Affinity DataIC50:  300nMAssay Description:Inhibition of LFA1 expressed in human JY cells interaction with ICAM1-IG expressed in human HeLa cell monolayer after 45 mins by cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed