BDBM50380592 CHEMBL1552719

SMILES COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccc(C)cc2)nnc1-c1ccncc1

InChI Key InChIKey=KRIKILRRJCIWNB-UHFFFAOYSA-N

Data  16 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50380592   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  460nMAssay Description:Inhibition of TNKS2 (unknown origin) by NAD+-dependent autopoly(ADP ribosyl)lation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSulfotransferase 2A1(Homo sapiens (Human))TBA
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  50nMAssay Description:Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  650nMAssay Description:Inhibition of GST-tagged TNKS2P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein Wnt-3a(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  548nMAssay Description:Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  990nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAxin-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataEC50:  566nMAssay Description:Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: >1.90E+4nMAssay Description:Inhibition of PARP1 autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: >1.90E+4nMAssay Description:Inhibition of PARP2 autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  650nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroidogenic factor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  790nMAssay Description:Uterotonic activity against OT receptor in Wistar rat in absence of magnesiumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  2.55E+3nMAssay Description:Uterotonic activity against OT receptor in Wistar rat in absence of magnesiumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  650nMAssay Description:Uterotonic activity against OT receptor in Wistar rat in absence of magnesiumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of GST-tagged TNKS1P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed