BDBM50381156 CHEMBL2018220::D3RKN_94

SMILES CSc1nn2c(nc(cc2=O)N2CCOCC2)n1Cc1cccc(c1C)C(F)(F)F

InChI Key InChIKey=JGXLVHIJLDKGLV-UHFFFAOYSA-N

Data  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50381156   

LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3Kbeta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataIC50:  320nMAssay Description:Inhibition of PI3Kalpha by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of PI3Kgamma by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of PI3K beta-mediated AKT phosphorylation at serine 473 in PTEN deficient human MDA-MB-468 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50381156(CHEMBL2018220 | D3RKN_94)
Affinity DataIC50:  25nMAssay Description:Inhibition of PI3Kdelta by continuous read time resolved fluorescence resonance energy transfer displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed