BDBM50381998 CHEMBL2022711

SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1

InChI Key InChIKey=PBHYAPKEUOBQSL-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50381998   

TargetAurora kinase A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381998(CHEMBL2022711)
Affinity DataIC50: <4nMAssay Description:Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381998(CHEMBL2022711)
Affinity DataIC50:  300nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381998(CHEMBL2022711)
Affinity DataEC50:  62nMAssay Description:Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381998(CHEMBL2022711)
Affinity DataIC50:  271nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381998(CHEMBL2022711)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381998(CHEMBL2022711)
Affinity DataIC50:  253nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50381998(CHEMBL2022711)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed