BDBM50382462 CHEMBL2023988::US10196373, Compound 27KI

SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCN(CC1)c1ccc(cc1)C(N)=O)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=SNSKABVPQWBANT-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50382462   

TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50382462(CHEMBL2023988 | US10196373, Compound 27KI)
Affinity DataKi:  1.01E+4nMAssay Description:Displacement of 5-carboxyfluorescein-labeled GpYLVLDKW from the STAT5b-SH2 domain after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50382462(CHEMBL2023988 | US10196373, Compound 27KI)
Affinity DataKi:  1.76E+4nMAssay Description:Displacement of fluorescein-labeled phosphotyrosine-peptide derived from the interleukin-6 receptor subunit gp130 from the STAT3 after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50382462(CHEMBL2023988 | US10196373, Compound 27KI)
Affinity DataKi:  2.78E+4nMAssay Description:Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50382462(CHEMBL2023988 | US10196373, Compound 27KI)
Affinity DataIC50: >3.00E+5nMAssay Description:ChIP assay was performed using EZ ChIP Kit (Millipore, Billerica, Mass., USA) as per manufacturer's instruction. Briefly, after crosslinking with...More data for this Ligand-Target Pair
In DepthDetails US Patent