BDBM50384898 CHEMBL2036270

SMILES CCN[C@H]1CC[C@H](CC1)c1c[nH]c2ccc(cc12)N=C(N)c1cccs1

InChI Key InChIKey=WKNJJZDFDCGVSZ-GASCZTMLSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50384898   

TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  4.93E+5nMAssay Description:Inhibition of human iNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  380nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  2.30E+4nMAssay Description:Displacement of [3H]astemizole from human Erg expressed in HEK293 cells after 75 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  2.15E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  2.31E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  927nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  540nMAssay Description:Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM50384898(CHEMBL2036270)
Affinity DataIC50:  2.34E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed