BDBM50389043 CHEMBL2064330

SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2ccccc12

InChI Key InChIKey=XLESLWHDVUIEMT-UHFFFAOYSA-N

Data  17 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50389043   

LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  76nMAssay Description:Inhibition of PI3Kbeta-mediated Akt phosphorylation at S473 in PTEN-deficient human PC3 cells after 0.5 to 2 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human recombinant CPY3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kalpha expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kdelta expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  99nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...More data for this Ligand-Target Pair
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  99nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PI3Kalpha-mediated Akt phosphorylation at Ser473 residue expressed in human H460 cells after 0.5 to 2 hrs by Western blot analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  86nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in mouse MEF-3T3 cells after 0.5 to 2 hrs by Western blot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  2.66E+3nMAssay Description:Inhibition of human PI3Kdelta-mediated Akt phosphorylation at Ser473 residue expressed in mouse MEF-3T3 cells after 0.5 to 2 hrs by Western blot anal...More data for this Ligand-Target Pair
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  188nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  76nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PI3Kgamma-mediated Akt phosphorylation at Ser473 residue expressed in mouse RAW264.7 cells after 0.5 to 2 hrs by Western blot ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389043(CHEMBL2064330)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of C-terminal ploy-His-tagged human PI3Kgamma expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed