BDBM50391846 CHEMBL2147041::US9133160, 31
SMILES Cc1ccncc1-c1cccc2n(CC(F)(F)F)cnc12
InChI Key InChIKey=OFFVLUDFSIUVMI-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50391846
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:The assays were performed in U-bottom 384-well optiplates. The final assay volume was 15 ul prepared from 7.5 ul additions of microsomes (prepared as...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human CYP17A1 expressed in HEK293 cell microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of CYP17A1 in human adrenal microsomes using [3H]-pregnenolone as substrate incubated for 90 mins by scintillation proximity assay in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of CYP17 transfected in human HEK2 cells using [3H]pregnenolone as substrate by SPA assayMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP17A1 in cynomolgus monkey using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity assay in presence of...More data for this Ligand-Target Pair
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: >7.50E+3nMAssay Description:Inhibition of CYP21A2 in human H295R cells using hydroxy progesterone as substrate incubated for 120 mins by LC-MS methodMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: >7.50E+3nMAssay Description:Inhibition of CYP11B1 in human H295R cells using deoxycorticosterone as substrate incubated for 48 hrs by LC-MS methodMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of CYP17A1 in cynomolgus monkey adrenal microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity a...More data for this Ligand-Target Pair