BDBM50391884 CHEMBL463574

SMILES C\C=C\c1ccc2oc(c(C)c2c1)-c1ccc(O)cc1

InChI Key InChIKey=KNFUWJAIDVAYOV-ONEGZZNKSA-N

Data  4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50391884   

TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50391884(CHEMBL463574)
Show SMILES C\C=C\c1ccc2oc(c(C)c2c1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H16O2/c1-3-4-13-5-10-17-16(11-13)12(2)18(20-17)14-6-8-15(19)9-7-14/h3-11,19H,1-2H3/b4-3+
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsomal membrane assessed as inhibition of PGE2 formation incubated for 15 mins before ad...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50391884(CHEMBL463574)
Show SMILES C\C=C\c1ccc2oc(c(C)c2c1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H16O2/c1-3-4-13-5-10-17-16(11-13)12(2)18(20-17)14-6-8-15(19)9-7-14/h3-11,19H,1-2H3/b4-3+
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50391884(CHEMBL463574)
Show SMILES C\C=C\c1ccc2oc(c(C)c2c1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H16O2/c1-3-4-13-5-10-17-16(11-13)12(2)18(20-17)14-6-8-15(19)9-7-14/h3-11,19H,1-2H3/b4-3+
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of sheep placental COX2 assessed as PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50391884(CHEMBL463574)
Show SMILES C\C=C\c1ccc2oc(c(C)c2c1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H16O2/c1-3-4-13-5-10-17-16(11-13)12(2)18(20-17)14-6-8-15(19)9-7-14/h3-11,19H,1-2H3/b4-3+
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of ram seminal vesicle COX1 assessed as PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair