BDBM50392143 CHEMBL2152773

SMILES OCc1ccc2nc(nc(N3CCOCC3)c2n1)-c1c(F)ccc2[nH]ccc12

InChI Key InChIKey=GILXWCHQBOQUSV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50392143   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50392143(CHEMBL2152773)Copy SMILESCopy InChI

Affinity DataIC50:  145nMAssay Description:Inhibition of PI3Kdelta-mediated AKT phosphorylation in B cells in presence of human serumMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50392143(CHEMBL2152773)Copy SMILESCopy InChI

Affinity DataIC50:  27nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI