BDBM50392453 CHEMBL2151923

SMILES Brc1cccc(NC(=O)Cc2nc(cc(=O)[nH]2)N2CCOCC2)c1

InChI Key InChIKey=NPBHHSSAUGKQQZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50392453   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50392453(CHEMBL2151923)
Affinity DataIC50:  23nMT: 2°CAssay Description:This test is based on measuring the expression of the AKT protein phosphorylated on serine 473. The phosphorylation of AKT (pAKT) is measured by west...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50392453(CHEMBL2151923)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50392453(CHEMBL2151923)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392453(CHEMBL2151923)
Affinity DataIC50:  189nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392453(CHEMBL2151923)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392453(CHEMBL2151923)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed