BDBM50393016 CHEMBL2152681::US9656959, Example 3

SMILES CC(C)C[C@H](NC(C)=O)C(=O)Nc1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1

InChI Key InChIKey=KVVOUURXKOZNPC-QHCPKHFHSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393016   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataKi:  194nMAssay Description:Blockade of Nav1.7 by electrophysiological patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataKi:  194nMAssay Description:In the alternative, the voltage clamp protocol to examine hNav1.7 currents was as follows. First, the standard current-voltage relationship was teste...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataIC50:  42nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataIC50:  42nMAssay Description:Blockade of Nav1.7 by FLIPR TETRA sodium dye assay in presence of KCl saltMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed