BDBM50395219 CHEMBL2164665::US9150581, RTI-7527-193

SMILES NS(=O)(=O)c1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2

InChI Key InChIKey=LSPFRPGGOBZZFJ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50395219   

TargetIsoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)(Rattus norvegicus (Rat))
Research Triangle Institute

US Patent
LigandPNGBDBM50395219(CHEMBL2164665 | US9150581, RTI-7527-193)
Affinity DataKi:  0.940nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395219(CHEMBL2164665 | US9150581, RTI-7527-193)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395219(CHEMBL2164665 | US9150581, RTI-7527-193)
Affinity DataKi: >2.00E+3nMAssay Description:Compounds (10 mM) were also evaluated for inhibition of binding to a7 nAChR using [125I]iodoMLA as previously reported in Carroll et al. The binding ...More data for this Ligand-Target Pair
In DepthDetails US Patent