BDBM50396169 CHEMBL1337170
SMILES [O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
InChI Key InChIKey=ZRRGOUHITGRLBA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50396169
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California
Curated by ChEMBL
University Of Southern California
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of STAT3 SH2 domain using 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2 as substrate preincubated for 60 mins prior to substrate addition by flu...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California
Curated by ChEMBL
University Of Southern California
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of IFNgamma-stimulated GFP/FLAG-tagged STAT3 dimerization in human AD293 cells incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Binding affinity to Cys255 residue of C-terminal Avi/FLAG-tagged HIF-1alpha (unknown origin) after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California
Curated by ChEMBL
University Of Southern California
Curated by ChEMBL
Affinity DataKd: 1.53E+3nMAssay Description:Binding affinity to His-tagged STAT3-SH2 domain (127 to 722 residues) (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California
Curated by ChEMBL
University Of Southern California
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibition of STAT3 in human Hep3B cells assessed as inhibition of IL-6 stimulated STAT3 expression by luciferase reporter assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California
Curated by ChEMBL
University Of Southern California
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of STAT3-SH2 (unknown origin) using 5-carboxyfluorescein-GY(PO3H2)EEIP as substrate incubated with compound for 1 hr followed by substrate...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California
Curated by ChEMBL
University Of Southern California
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of STAT3 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California
Curated by ChEMBL
University Of Southern California
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of STAT3 (unknown origin) expressed in mouse NIH3T3 cells assessed as reduction in DNA binding activity incubated for 20 mins in presence ...More data for this Ligand-Target Pair
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
University Of Cape Town
Curated by ChEMBL
University Of Cape Town
Curated by ChEMBL
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair