BDBM50399407 CHEMBL2178284::MUT056399

SMILES CCc1cc(O)c(Oc2ccc(cc2F)C(N)=O)cc1F

InChI Key InChIKey=QUHARGDBJJUOEB-UHFFFAOYSA-N

Data  1 KI  5 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50399407   

TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Burkholderia pseudomallei)
Stony Brook University

LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataKi:  405nM ΔG°:  -8.71kcal/molepH: 8.0 T: 2°CAssay Description:Slow-onset inhibition kinetics were monitored at 340 nm on a Cary 100 spectrophotometer (Varian) at 25 °C in 30 mM PIPES buffer (pH 8.0) containing 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Center For Free-Electron Laser Science

LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataEC50:  3.82E+4nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold ...More data for this Ligand-Target Pair
LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50:  58nMAssay Description:Inhibition of Escherichia coli DH5alpha FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50:  58nMAssay Description:Inhibition of Escherichia coli FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50:  12nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50:  12nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50:  12nMAssay Description:Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed