BDBM50400313 CHEMBL2181329

SMILES CCN(CC)CCOc1ccc2Nc3nccc(n3)-c3cccc(COCC=CCOCc1c2)c3

InChI Key InChIKey=MLIJDZYVRSRDJT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50400313   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400313(CHEMBL2181329)
Affinity DataIC50:  620nMAssay Description:Inhibition of recombinant JAK3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400313(CHEMBL2181329)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of recombinant JAK1 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400313(CHEMBL2181329)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant JAK2 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400313(CHEMBL2181329)
Affinity DataIC50:  79nMAssay Description:Inhibition of recombinant TYK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400313(CHEMBL2181329)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as decrease in formation of 1-hydroxymidazolam from midazolam substrate after 5 mins by LC-MS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400313(CHEMBL2181329)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant FLT3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400313(CHEMBL2181329)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as decrease in formation of dextrorphan from dextromethorphan substrate after 30 mins by LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed