BDBM50401256 CHEMBL2206904::US8772480, 331

SMILES COc1cnc(Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)c(c1)-c1nc(C)nc(N)n1

InChI Key InChIKey=BHEMPSVJQFJQIN-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50401256   

LigandPNGBDBM50401256(CHEMBL2206904 | US8772480, 331)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta expressed in baculovirus infected Hi5 cells using Phosphatidylinositol-4,5-bisphosphate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401256(CHEMBL2206904 | US8772480, 331)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110gamma expressed in baculovirus infected Hi5 cells using Phosphatidylinositol-4,5-bisphosphate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401256(CHEMBL2206904 | US8772480, 331)
Affinity DataKi:  4.70nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110beta expressed in baculovirus infected Hi5 cells using Phosphatidylinositol-4,5-bisphosphate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401256(CHEMBL2206904 | US8772480, 331)
Affinity DataKi:  9.30nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110alpha expressed in baculovirus infected Hi5 cells using Phosphatidylinositol-4,5-bisphosphate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401256(CHEMBL2206904 | US8772480, 331)
Affinity DataKi:  14nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50401256(CHEMBL2206904 | US8772480, 331)
Affinity DataIC50:  64nMAssay Description:The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50401256(CHEMBL2206904 | US8772480, 331)
Affinity DataIC50:  74nMAssay Description:Inhibition of recombinant N-terminal GST-tagged mTOR using GFP-4EBP as substrate after 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed