BDBM50405035 CHEMBL266573

SMILES COc1ccc(cc1)N1C(N)=NC(N)=NC1(C)C

InChI Key InChIKey=KLCSZLKQTXQCTD-UHFFFAOYSA-N

Data  4 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50405035   

TargetDihydrofolate reductase(Gallus gallus (Chicken))
TBA

Curated by ChEMBL
LigandPNGBDBM50405035(CHEMBL266573)
Affinity DataKi:  331nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50405035(CHEMBL266573)
Affinity DataKi:  4.02E+3nMAssay Description:Inhibition of Escherichia coli DHFR assessed as NADP formation by quadratic Morrison plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405035(CHEMBL266573)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibitory activity against human lymphoblastoid cell (WIL2) dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405035(CHEMBL266573)
Affinity DataKi:  7.94E+4nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50405035(CHEMBL266573)
Affinity DataKd:  1.72E+4nMAssay Description:Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50405035(CHEMBL266573)
Affinity DataIC50:  8.91E+4nMAssay Description:Inhibition of Escherichia coli DHFR assessed as NADP formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed