BDBM50419860 CHEMBL1957471

SMILES COc1cccc(-c2cccc(c2)[C@@]2(N=C(N)N3CC(F)(F)CN=C23)c2ccncc2)c1F

InChI Key InChIKey=RECVUKARQVUVBY-DEOSSOPVSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50419860   

TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419860(CHEMBL1957471)
Affinity DataIC50:  54nMAssay Description:Inhibition of BACE-1-mediated sAPPbeta production in human SH-SY5Y cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419860(CHEMBL1957471)
Affinity DataIC50:  41nMAssay Description:Inhibition of human BACE-1 using (Eu)CEVNLDAEFK(Qsy7) as substrate preincubated for 10 mins prior substrate addition measured after 15 mins by FRET-b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419860(CHEMBL1957471)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE-1 using (Eu)CEVNLDAEFK(Qsy7) as substrate preincubated for 10 mins prior substrate addition measured after 15 mins by FRET-b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419860(CHEMBL1957471)
Affinity DataIC50:  31nMAssay Description:Inhibition of BACE-1-mediated sAPPbeta production in human SH-SY5Y cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed