BDBM50424538 CHEMBL2312140
SMILES COc1cc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)CC1
InChI Key InChIKey=ZLZJYPLAARWUEF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50424538
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 4.73E+3nMAssay Description:Inhibition of PAK1 in human OVCAR3 cells assessed as MEK phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of TNIK (unknown origin) by ADP glo luminescent assayMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataKd: 86nMAssay Description:Competitive binding affinity to TNIK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of TNIK-mediated TCF4/beta-catenin transcription in human HCT116 cells by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair