BDBM50424957 CHEMBL2316158::US9409845, Table 1, Compound 19: (2E,6E)-2-(3,5-dimethoxybenzylidene)-6-(4-methylsulphonylbenzylidene)cyclohexanone

SMILES COc1cc(OC)cc(\C=C2/CCC\C(=C/c3ccc(cc3)S(C)(=O)=O)C2=O)c1

InChI Key InChIKey=KCKFFUAUNCDZHZ-GDAWTGGTSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50424957   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmaxyn Laboratories

US Patent
LigandPNGBDBM50424957(CHEMBL2316158 | US9409845, Table 1, Compound 19: (...)
Affinity DataIC50:  1.96E+3nMT: 2°CAssay Description:The kinase activity of EGFR was detected according to time-resolved fluorescence detection technology to evaluate automatic phosphorylation levels. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50424957(CHEMBL2316158 | US9409845, Table 1, Compound 19: (...)
Affinity DataIC50:  11nMAssay Description:Inhibition of xanthine oxidase (unknown origin) assessed as reduction in uric acid formation preincubated for 5 mins followed by addition of xanthine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmaxyn Laboratories

US Patent
LigandPNGBDBM50424957(CHEMBL2316158 | US9409845, Table 1, Compound 19: (...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of EGFR cytoplasmic domain (amino acids 645 to 1186) (unknown origin) expressed in Sf9 cells assessed as reduction in enzyme autophosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed