BDBM50425861 CHEMBL2312645

SMILES COc1ccccc1CNc1ncc(C(=O)NC2CCN(C)CC2)c(NC2CCCC2)n1

InChI Key InChIKey=IHJZXCJKSRQJCM-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50425861   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  520nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of LCK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of INSR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of IKK-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of GSK3-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CK1-delta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Aurora-A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  2.11E+4nMAssay Description:Inhibition of ABL (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP-selectin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425861(CHEMBL2312645)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed