BDBM50427453 CHEMBL2322228::US10308662, Compound 28::US9505780, 28
SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1
InChI Key InChIKey=BYTKNUOMWLJVNQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 50427453
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 241nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 34nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 214nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 960nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 158nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 289nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 960nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 214nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 241nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 34nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 214nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 960nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 158nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 158nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Signal Rx Pharmaceuticals
US Patent
Signal Rx Pharmaceuticals
US Patent
Affinity DataIC50: 1.55E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair