BDBM50427488 CHEMBL2326956::US10308662, Compound 100::US9505780, 100

SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1

InChI Key InChIKey=GCNBLUDADAFSDA-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50427488   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  1.09E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  2.76E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  55.2nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  295nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  259nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  259nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  240nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  2.76E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  55.2nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  295nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427488(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Affinity DataIC50:  80nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed