BDBM50428342 CHEMBL2331710

SMILES NC1=NC2(CC2CCS1)c1cccc(NC(=O)c2ccc(Cl)cn2)c1

InChI Key InChIKey=WQDXYYJHDFSNIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50428342   

TargetBeta-secretase 2(Rattus norvegicus)
Temple University

Curated by ChEMBL
LigandPNGBDBM50428342(CHEMBL2331710)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE2-mediated TMEM27 cleavage in rat INS-1E cells expressing doxycycline-dependent human full-length TMEM27 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50428342(CHEMBL2331710)
Affinity DataIC50:  50nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP695 assessed as decrease in amyloid beta 40 level after 18 to 20 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed