BDBM50428594 CHEMBL2337981

SMILES CC(C)(C)NC(=O)NCCN1CCC(CO)(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1

InChI Key InChIKey=RAZOFRCGTLUGNK-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50428594   

TargetCytochrome P450 2C8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50:  600nMAssay Description:Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >3.16E+4nMAssay Description:Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of T-type calcium channel Cav3.2 (unknown origin) by IONWORKS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant CYP2D6-mediated 7-methoxy-4(aminomethyl)-coumarine degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by IONWORKS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428594(CHEMBL2337981)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed