BDBM50429615 CHEMBL2334586
SMILES CC(C)(O)C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
InChI Key InChIKey=DGLFSNZWRYADFC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50429615
Affinity DataIC50: 170nMAssay Description:Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 s...More data for this Ligand-Target Pair
Affinity DataIC50: 316nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human wild type partial length PIKfyve (F1512 to C2098 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TAO1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human wild type TAOK1 (M1 to A320 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TAO3(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of human wild type partial length TAOK3 (M1 to T316 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 6(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human wild type partial length PAK6 (N298 to C681 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TAO2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of human wild type partial length TAOK2 (M1 to A320 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetTestis-specific serine/threonine-protein kinase 3(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of wild-type human full length TSSK3 (M1 to T268 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 5(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of human wild type partial length PAK5 (Y400 to H719 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human wild type partial length PAK4 (Q144 to R438 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetTestis-specific serine/threonine-protein kinase 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human wild type TSSK1More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit PRKX(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 580nMAssay Description:Inhibition of human wild type partial length PRKX (M1 to F358 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 199nMAssay Description:Inhibition of GST-tagged TTBK1 (1 to 421) (unknown origin) using DNA Topoisomerase 2-alpha-Thr1342 as substrate incubated for 15 mins followed by ATP...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of TTBK1 in human HEK293T cells incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair