BDBM50429760 CHEMBL2336357::N-(4-Methoxyphenyl)Cinnamamide

SMILES COc1ccc(NC(=O)\C=C\c2ccccc2)cc1

InChI Key InChIKey=WEMJCDDYUBVWRB-KPKJPENVSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50429760   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429760(CHEMBL2336357 | N-(4-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50429760(CHEMBL2336357 | N-(4-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  9.05E+3nMAssay Description:Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429760(CHEMBL2336357 | N-(4-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429760(CHEMBL2336357 | N-(4-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed