BDBM50429762 CHEMBL2336355::N-(2-Methoxyphenyl)Cinnamamide

SMILES COc1ccccc1NC(=O)\C=C\c1ccccc1

InChI Key InChIKey=RMBQQMJNYKVGEL-VAWYXSNFSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50429762   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429762(CHEMBL2336355 | N-(2-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429762(CHEMBL2336355 | N-(2-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50429762(CHEMBL2336355 | N-(2-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  5.16E+3nMAssay Description:Inhibition of recombinant His-tagged human EGFR (645 to 1186 residues) cytoplasmic domain expressed in baculovirus infected Sf9 cells incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50429762(CHEMBL2336355 | N-(2-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  5.16E+3nMAssay Description:Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429762(CHEMBL2336355 | N-(2-Methoxyphenyl)Cinnamamide)
Affinity DataIC50:  5.18E+3nMAssay Description:Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed