BDBM50430176 CHEMBL589733::MMV665807::SJ000010289

SMILES Oc1ccc(Cl)cc1C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=OAMVIBKEICGPKK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50430176   

TargetTransmembrane protease serine 4(Homo sapiens (Human))
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50430176(CHEMBL589733 | MMV665807 | SJ000010289)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant TMPRSS4 (unknown origin) fused with enterokinase cleavage sequence DYKDDDGDYKDDDDK expressed in Esch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50430176(CHEMBL589733 | MMV665807 | SJ000010289)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at non-desensitizing human P2X1 receptor ( P2X2/P2X1 chimera) expressed in human 1321N1 cells assessed as inhibition of ATP-induc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50430176(CHEMBL589733 | MMV665807 | SJ000010289)
Affinity DataIC50:  6.32E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50430176(CHEMBL589733 | MMV665807 | SJ000010289)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50430176(CHEMBL589733 | MMV665807 | SJ000010289)
Affinity DataIC50:  537nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50430176(CHEMBL589733 | MMV665807 | SJ000010289)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed