BDBM50431029 CHEMBL574646

SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1

InChI Key InChIKey=GXFKPANENAOEOK-UTLPMFLDSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50431029   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of recombinant MAPKAPK2 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of recombinant MAPK14 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  660nMAssay Description:Inhibition of recombinant KDR (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant NEK1 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant ERK2 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant MEK1 (unknown origin) by cascade reaction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxiredoxin-1(Homo sapiens)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  950nMAssay Description:Inhibition of PRDX1 in human PMA-differentiated LPS-stimulated THP1 cells assessed as reduction in NLRP3 inflammasome activation preincubated for 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of recombinant AMPK A1/B1/G1 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant RPS6K1 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant IKBKB (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant AKT2 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant AKT1 (unknown origin) by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50431029(CHEMBL574646)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant RAF1 (unknown origin) by cascade reaction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed