BDBM50434582 CHEMBL2386594

SMILES Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(n1)-c1cccnc1

InChI Key InChIKey=BQQYXPHRXIZMDM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50434582   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Acelot

Curated by ChEMBL
LigandPNGBDBM50434582(CHEMBL2386594)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Acelot

Curated by ChEMBL
LigandPNGBDBM50434582(CHEMBL2386594)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of wild type LRRK2 (unknown origin) assessed as inhibition of LRRKtide phosphorylation after 120 mins by radiometric assay in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50434582(CHEMBL2386594)
Affinity DataIC50:  2.23E+3nMAssay Description:Inhibition of human BCR-ABL1 autophosphorylation expressed in mouse BA/F3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50434582(CHEMBL2386594)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of human BCR-ABL1 expressed in mouse BA/F3 cells assessed as cell growth inhibition by ATP-depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50434582(CHEMBL2386594)
Affinity DataIC50:  512nMAssay Description:Inhibition of human BCR-ABL1 (unknown origin) expressed in mouse 32D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed