BDBM50436053 CHEMBL2396992

SMILES Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN

InChI Key InChIKey=JCTJISIFGZHOFY-UHFFFAOYSA-N

Data  3 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50436053   

TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50:  1.55E+5nMAssay Description:Inhibition of KRas (unknown origin) by nucleotide release assayMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50:  1.55E+5nMAssay Description:Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of SOS-mediated nucleotide release activityMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataEC50:  1.58E+4nMAssay Description:Inhibition of KRas activation in HEK 293T-REx Flp-In cells harboring Venus-RBD-CRD/mCherry-CAAX assessed as reduction in Venus-RBD-CRD recruitment to...More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50:  3.42E+5nMAssay Description:Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of nucleotide exchange activityMore data for this Ligand-Target Pair