BDBM50440862 CHEMBL2431717

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)NCc1ccccc1OC

InChI Key InChIKey=CVXCZFZFHKSABI-XZOYJPPVSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50440862   

TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  4.50E+3nMAssay Description:Displacement of europium-labeled 2f-LIGRLO-NH2 from human PAR2 expressed in CHO cells after 1 to 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of trypsin-induced ca2+ release preincubated for 15 mins measured after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of trypsin-induced ca2+ release preincubated for 15 mins measured after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of SLIGKV-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  500nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced ca2+ release preincubated for 15 mins measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of trypsin-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50440862(CHEMBL2431717)
Affinity DataIC50:  501nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-induced ca2+ release preincubated for 15 mins measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed