BDBM50442179 CHEMBL2441619

SMILES Cc1ccc2nc(cc(N3CCNCC3)c2c1)C(F)(F)F

InChI Key InChIKey=ZKHOZLXKYFBVMY-UHFFFAOYSA-N

Data  1 KI  4 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50442179   

TargetHistamine H1 receptor(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataKi:  399nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Uit The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataKd:  3.33E+5nMAssay Description:Binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50:  2.04E+5nMAssay Description:Inhibition of Axl (unknown origin) using 5'FAM labeled KKKKEEIYFFF-NH2 peptide as substrate incubated for 1.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
A*Star

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 (unknown origin) (72 to 385 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*Star

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of N-terminal GST-tagged MNK1 (unknown origin) (37 to 341 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Uit The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50:  5.92E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed