BDBM50443627 CHEMBL3092450::US9216998, 5

SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F

InChI Key InChIKey=MXODNNNPSJJTNP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443627   

TargetEndothelial lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50:  14nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50:  14nMAssay Description:Inhibition of human endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Mus musculus (Mouse))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50:  17nMAssay Description:Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Mus musculus (Mouse))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50:  17nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
In DepthDetails US Patent