BDBM50445209 CHEMBL3103625::US9540323, Comparator 2::US9540323, example comparator 2

SMILES CC1(C)CN(c2ccccc12)c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=GYKCLACFAZJLOM-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50445209   

TargetP2Y purinoceptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50445209(CHEMBL3103625 | US9540323, Comparator 2 | US954032...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [33P]-2MeS-ADP from human P2Y1 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50445209(CHEMBL3103625 | US9540323, Comparator 2 | US954032...)
Affinity DataKi:  8.70nM ΔG°:  -11.0kcal/molepH: 7.4 T: 2°CAssay Description:A SPA membrane binding assay was used to identify inhibitors of [33P] 2MeS-ADP binding to cloned human P2Y1 receptors (The P2Y1 receptor membranes we...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50445209(CHEMBL3103625 | US9540323, Comparator 2 | US954032...)
Affinity DataIC50:  8.50E+3nMAssay Description:Antagonist activity at P2Y1 receptor in platelet-enriched human plasma assessed as 2.5 uM ADP-induced platelet aggregation preincubated for 1 min fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed