BDBM50446891 CHEMBL3115314::US10246442, Example 61::US10975062, Example 61

SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1

InChI Key InChIKey=YEHGRYMGRBBRMA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50446891   

TargetEgl nine homolog 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50446891(CHEMBL3115314 | US10246442, Example 61 | US1097506...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PHD2 (181 to 417) (unknown origin) using HIF-1alpha peptide as substrate assessed as 2-Oxoglutarate conversion to succinic acid preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50446891(CHEMBL3115314 | US10246442, Example 61 | US1097506...)
Affinity DataIC50:  50.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEgl nine homolog 1 [182-426](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50446891(CHEMBL3115314 | US10246442, Example 61 | US1097506...)
Affinity DataIC50:  50.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In DepthDetails US Patent